PPIRE19322
Target Protein Information
| Protein_Name | H-2 class I histocompatibility antigen D-D alpha chain |
|---|---|
| Protein_Sequence | MGAMAPRTLLLLLAAALGPTQTRAGSHSLRYFVTAVSRPGFGEPRYMEVGYVDNTEFVRFDSDAENPRYEPRARWIEQEGPEYWERETRRAKGNEQSFRVDLRTALRYYNQSAGGSHTLQWMAGCDVESDGRLLRGYWQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQAGAAERDRAYLEGECVEWLRRYLKNGNATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRPAGDGTFQKWASVVVPLGKEQKYTCHVEHEGLPEPLTLRWGKEEPPSSTKTNTVIIAVPVVLGAVVILGAVMAFVMKRRRNTGGKGGDYALAPGSQSSDMSLPDCKV |
| Organism_Source | Mus musculus |
| Functional_Classification | MHC class1 |
| Cellular_Localization | Plasma membrane |
| Gene_Names | H2-D1 |
| UniProt_ID | P01900 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | GP33 Alpha/Beta-peptide 9d |
|---|---|
| Peptide_Sequence | KXAVXFXM |
| Peptide_Length | 8 |
| Peptide_SMILES | CSCC[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](N)CCCCN)C(C)C)C(=O)O |
| Chemical_Modification | X1=Beta3-homoLysine; X5=Beta3-homoTyrosine; X7=Beta3-homoAlanine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 765.93 |
|---|---|
| Aliphatic_Index | 48.75000 |
| Aromaticity | 0.12500 |
| Average_Rotatable_Bonds | 3.12500 |
| Charge_at_pH_7 | 0.99769 |
| Isoelectric_Point | 9.70000 |
|---|---|
| Hydrogen_Bond_Acceptors | 11 |
| Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 293.04000 |
| X_logP_energy | -2.51320 |
Interaction Information
| Affinity | IC50=18500 nM |
|---|---|
| Affinity_Assay | Competition binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Consequences of Periodic Alpha-to-Beta3 Residue Replacement for Immunological Recognition of Peptide Epitopes |
| Release_Year | 2014 |
| PMID | 25559929 |
| DOI | 10.1021/cb500888q |