PPIRE19363

Target Protein Information
Protein_Name Melanocortin receptor 5
Protein_Sequence MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
Organism_Source Mus musculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Mc5r
UniProt_ID P41149
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name VA-Alpha-MSH
Peptide_Sequence VAAEKKDEGPYRMEHFRWGSPPKD
Peptide_Length 24
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2831.16
Aliphatic_Index 20.41667
Aromaticity 0.12500
Average_Rotatable_Bonds 3.75000
Charge_at_pH_7 0.09337
Isoelectric_Point 7.54196
Hydrogen_Bond_Acceptors 39
Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1179.54000
X_logP_energy -9.89056
Interaction Information
Affinity EC50=24.3 nM
Affinity_Assay lipolysis assay (glycerol release)
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Isolation and Characterization of a Novel Proopiomelanocortin-Derived Peptide from Hemofiltrate of Chronic Renal Failure Patients
Release_Year 2005
PMID 15650078
DOI 10.1210/en.2004-1097