PPIRE19367

Target Protein Information
Protein_Name Gonadotropin-releasing hormone receptor
Protein_Sequence MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names GNRHR
UniProt_ID P30968
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name gonadorelin
Peptide_Sequence PHWSYGLRPG
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1169.31
Aliphatic_Index 39.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.10000
Charge_at_pH_7 1.08804
Isoelectric_Point 9.35118
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 449.27000
X_logP_energy -3.10503
Interaction Information
Affinity IC50=1.641 nM
Affinity_Assay FLIPR assay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Optimized functional and structural design of dual-target LMRAP a bifunctional fusion protein with a 25-amino-acid antitumor peptide and GnRH Fc fragment
Release_Year 2020
PMID 32082972
DOI 10.1016/j.apsb.2019.10.010