PPIRE19374

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 2A
Protein_Sequence KTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGLDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA
Organism_Source Mus musculus
Functional_Classification monoclonal antibody
Cellular_Localization Extracellular
Gene_Names Ighg2a
UniProt_ID P01865
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Phage15
Peptide_Sequence MVPLHDPHHFLKHSY
Peptide_Length 15
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1858.15
Aliphatic_Index 71.33333
Aromaticity 0.13333
Average_Rotatable_Bonds 3.60000
Charge_at_pH_7 0.36092
Isoelectric_Point 7.86972
Hydrogen_Bond_Acceptors 25
Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 671.64000
X_logP_energy -2.65060
Interaction Information
Affinity EC50=980 pM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Selection of Peptidic Mimics of Digoxin from Phage-displayed Peptide Libraries by Anti-digoxin Antibodies
Release_Year 2000
PMID 10926495
DOI 10.1006/jmbi.2000.3934