PPIRE19376

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 2A
Protein_Sequence KTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGLDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA
Organism_Source Mus musculus
Functional_Classification monoclonal antibody
Cellular_Localization Extracellular
Gene_Names Ighg2a
UniProt_ID P01865
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Phage22
Peptide_Sequence SSPKPVVVHLVRDNI
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](N)CO)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1659.95
Aliphatic_Index 129.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 1.08904
Isoelectric_Point 9.69702
Hydrogen_Bond_Acceptors 23
Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 690.59000
X_logP_energy -6.39313
Interaction Information
Affinity EC50=21 pM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Selection of Peptidic Mimics of Digoxin from Phage-displayed Peptide Libraries by Anti-digoxin Antibodies
Release_Year 2000
PMID 10926495
DOI 10.1006/jmbi.2000.3934