PPIRE19377

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 2A
Protein_Sequence KTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGLDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA
Organism_Source Mus musculus
Functional_Classification monoclonal antibody
Cellular_Localization Extracellular
Gene_Names Ighg2a
UniProt_ID P01865
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Phage25
Peptide_Sequence GLEQVEFASAVATRSADRACRPFEFC
Peptide_Length 26
Peptide_SMILES CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2861.20
Aliphatic_Index 56.53846
Aromaticity 0.11538
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -1.12020
Isoelectric_Point 4.58749
Hydrogen_Bond_Acceptors 40
Hydrogen_Bond_Donors 45
Topological_Polar_Surface_Area 1220.71000
X_logP_energy -13.80899
Interaction Information
Affinity EC50=17 pM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Selection of Peptidic Mimics of Digoxin from Phage-displayed Peptide Libraries by Anti-digoxin Antibodies
Release_Year 2000
PMID 10926495
DOI 10.1006/jmbi.2000.3934