PPIRE19392
Target Protein Information
| Protein_Name | Neuroendocrine convertase 1 |
|---|---|
| Protein_Sequence | MEQRGWTLQCTAFAFFCVWCALNSVKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPRRSRRSALHITKRLSDDDRVTWAEQQYEKERSKRSVQKDSALDLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLASNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVKDNNFEPRALKANGEVIVEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKITDMSGRMQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVNVVEKRPTQKSLNGNLLVPKNSSSSNVEGRRDEQVQGTPSKAMLRLLQSAFSKNALSKQSPKKSPSAKLSIPYESFYEALEKLNKPSKLEGSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNEEN |
| Organism_Source | Mus musculus |
| Functional_Classification | serine proteases |
| Cellular_Localization | Extracellular |
| Gene_Names | Pcsk1 |
| UniProt_ID | P63239 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | mPC1(84-99) |
|---|---|
| Peptide_Sequence | SVQKDSALDLFNDPMTY |
| Peptide_Length | 17 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1944.14 |
|---|---|
| Aliphatic_Index | 68.82353 |
| Aromaticity | 0.11765 |
| Average_Rotatable_Bonds | 3.64706 |
| Charge_at_pH_7 | -2.00182 |
| Isoelectric_Point | 3.82610 |
|---|---|
| Hydrogen_Bond_Acceptors | 29 |
| Hydrogen_Bond_Donors | 27 |
| Topological_Polar_Surface_Area | 825.15000 |
| X_logP_energy | -8.56710 |
Interaction Information
| Affinity | IC50=2.3 uM |
|---|---|
| Affinity_Assay | radioimmunoassay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Application of the multiple antigenic peptides (MAP) strategy to the production of prohormone convertases antibodies: synthesis characterization and use of 8-branched immunogenic peptides |
| Release_Year | 1995 |
| PMID | 9223018 |
| DOI | 10.1002/psc.310010606 |