PPIRE19412
Target Protein Information
| Protein_Name | Urotensin-2 receptor |
|---|---|
| Protein_Sequence | MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | UTS2R |
| UniProt_ID | Q9UKP6 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | [Orn5]URP |
|---|---|
| Peptide_Sequence | ACFWXYCV |
| Peptide_Length | 8 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)C(=O)O |
| Chemical_Modification | X5=ornithine |
| Cyclization_Method | Side chain side chain cyclization; C2<-->X5; other bonds |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 948.12 |
|---|---|
| Aliphatic_Index | 48.75000 |
| Aromaticity | 0.37500 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -0.12682 |
| Isoelectric_Point | 5.82405 |
|---|---|
| Hydrogen_Bond_Acceptors | 12 |
| Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 303.04000 |
| X_logP_energy | -0.12620 |
Interaction Information
| Affinity | EC50=57.54 nM |
|---|---|
| Affinity_Assay | Radioligand binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structure-鍌欒兌閸嬨劑宕曢懠韬蹭汗缂佹柨绐恑vity relationships and structural conformation of a novel urotensin II related peptide |
| Release_Year | 2004 |
| PMID | 15476952 |
| DOI | 10.1016/j.peptides.2004.04.019 |