PPIRE19446

Target Protein Information
Protein_Name Caltractin
Protein_Sequence MSYKAKTVVSARRDQKKGRVGLTEEQKQEIREAFDLFDTDGSGTIDAKELKVAMRALGFEPKKEEIKKMISEIDKDGSGTIDFEEFLTMMTAKMGERDSREEILKAFRLFDDDNSGTITIKDLRRVAKELGENLTEEELQEMIAEADRNDDNEIDEDEFIRIMKKTSLF
Organism_Source Chlamydomonas reinhardtii
Functional_Classification EF hand calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names None
UniProt_ID P05434
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name K19
Peptide_Sequence KKRELIESKWHRLLFHDKK
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2491.97
Aliphatic_Index 82.10526
Aromaticity 0.10526
Average_Rotatable_Bonds 4.73684
Charge_at_pH_7 4.18232
Isoelectric_Point 10.95759
Hydrogen_Bond_Acceptors 33
Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1046.30000
X_logP_energy -5.42446
Interaction Information
Affinity KD=100 uM
Affinity_Assay fluorescence spectroscopy
PDB_ID 1OQP
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Mechanisms of Signal Transduction: The Mode of Action of Centrin: BINDING OF Ca2+ AND A PEPTIDE FRAGMENT OF Kar1p TO THE C-TERMINAL DOMAIN
Release_Year 2004
PMID 15452116
DOI 10.1074/jbc.M404233200