PPIRE19449

Target Protein Information
Protein_Name HLA class II histocompatibility antigen DRB1 beta chain
Protein_Sequence MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
Organism_Source Homo sapiens
Functional_Classification MHC class 2 molecules
Cellular_Localization Plasma membrane
Gene_Names HLA-DRB1
UniProt_ID P01911
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name hTSH-R peptide 37
Peptide_Sequence ISRIYVSIDVTLQQLES
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1964.25
Aliphatic_Index 148.82353
Aromaticity 0.05882
Average_Rotatable_Bonds 3.88235
Charge_at_pH_7 -1.00065
Isoelectric_Point 4.18441
Hydrogen_Bond_Acceptors 28
Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 852.75000
X_logP_energy -7.86263
Interaction Information
Affinity IC50=0.3 uM
Affinity_Assay in vitro peptide-鍌欒兌閸嬨劑宕曢懠韬蹭汗闁革附 binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title THYROID-TRH-TSH Epitope Recognition in HLA-DR3 Transgenic Mice Immunized to TSH-R Protein or Peptides
Release_Year 2013
PMID 23592747
DOI 10.1210/en.2013-1033