PPIRE19451

Target Protein Information
Protein_Name Apical membrane antigen 1
Protein_Sequence CPVFGKGIIIENSKTTFLTPVATENQDLKDGGFAFPPTKPLMSPMTLDHMRDFYKDNEYVKNLDELTLCSRHAGNMNPDNDKNSNYKYPAVYDYNDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAKDISFQNYTYLSKNVVDNWEKVCPRKNLQNAKFGLWVDGNCEDIPHVNEFSANDLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETHKCEIFNVKPTCLINNSSYIATTALSHPIEVENNFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKCPCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDNMKIIIASSAAVAVLATILMVYLYKRKGNAEKYDKMDEPQHYGKSNSRNDEMLD
Organism_Source Plasmodium falciparum
Functional_Classification erythrocyte binding proteins
Cellular_Localization Plasma membrane
Gene_Names AMA1
UniProt_ID A0A0X8IHV3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide 4325
Peptide_Sequence MIKSAFLPTGAFKADRYKSH
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2268.66
Aliphatic_Index 54.00000
Aromaticity 0.15000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 3.08760
Isoelectric_Point 10.63650
Hydrogen_Bond_Acceptors 32
Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 894.29000
X_logP_energy -7.45803
Interaction Information
Affinity KD=100 nM
Affinity_Assay erythrocyte binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Protection against experimental P. falciparum malaria is associated with short AMA-1 peptide analogue a-helical structures
Release_Year 2003
PMID 12628294
DOI 10.1016/S0300-9084(03)00002-6