PPIRE19452

Target Protein Information
Protein_Name Melanocortin receptor 3
Protein_Sequence MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFIIYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG
Organism_Source Mus musculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Mc3r
UniProt_ID P33033
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tyr-c[(cid:226)-Asp-Pro-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2
Peptide_Sequence YDPfRWNAFXY
Peptide_Length 11
Peptide_SMILES C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method Main chain-side chain cyclization; D2<-->X10; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1435.56
Aliphatic_Index 9.09091
Aromaticity 0.45455
Average_Rotatable_Bonds 3.45455
Charge_at_pH_7 -0.00327
Isoelectric_Point 6.32528
Hydrogen_Bond_Acceptors 17
Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 544.07000
X_logP_energy -1.87683
Interaction Information
Affinity Ki=63 nM
Affinity_Assay Schild analysis
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structure-Activity Relationships of the Unique and Potent Agouti-Related Protein (AGRP)-Melanocortin Chimeric Tyr-c[(cid:226)-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Peptide Template
Release_Year 2005
PMID 15828845
DOI 10.1021/jm049010r