PPIPT00004

Target Protein Information
Protein_Name Potassium voltage-gated channel subfamily A member 3
Protein_Sequence MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
Organism_Source Homo sapiens
Functional_Classification Voltage-gated potassium channel
Cellular_Localization Plasma membrane
Gene_Names KCNA3
UniProt_ID P22001
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AnTx K16D/N17A/F32Y mutant
Peptide_Sequence EKECTGPOHCTNFCRDAKCTHGKCMNRKCKCYNCK
Peptide_Length 35
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method Multi-point cyclization; C4<->C19; disulfide bond; C10<->C31; disulfide bond; C14<->C24; disulfide bond; C29<->C34; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3998.67
Aliphatic_Index 2.85714
Aromaticity 0.05714
Average_Rotatable_Bonds 3.88571
Charge_at_pH_7 4.68537
Isoelectric_point 8.59790
Hydrogen_Bond_Acceptors 65
Hydrogen_Bond_Donors 67
Topological_Polar_Surface_Area 1703.30000
X_logP_energy -23.11066
Interaction Information
Affinity KD=1.4 nM
Affinity_Assay whole-cell patch clamp
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title MODIFIED PEPTIDE TOXINS
Release_Year 2015
Patent_ID US20150087603A1