PPIPT00368
Target Protein Information
| Protein_Name | GTPase KRas |
|---|---|
| Protein_Sequence | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM |
| Organism_Source | Homo sapiens |
| Functional_Classification | Small GTPase (Ras family) |
| Cellular_Localization | Plasma membrane |
| Gene_Names | KRAS |
| UniProt_ID | P01116 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | G12V-T15 |
|---|---|
| Peptide_Sequence | TEYKLVVVGAVGV |
| Peptide_Length | 13 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1333.59 |
|---|---|
| Aliphatic_Index | 149.23077 |
| Aromaticity | 0.07692 |
| Average_Rotatable_Bonds | 3.23077 |
| Charge_at_pH_7 | -0.00139 |
| Isoelectric_point | 6.40200 |
|---|---|
| Hydrogen_Bond_Acceptors | 18 |
| Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 516.30000 |
| X_logP_energy | -2.85240 |
Interaction Information
| Affinity | EC50=0.288 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | RAS MUTANT EPITOPE PEPTIDE AND T CELL RECEPTOR RECOGNIZING RAS MUTANT |
| Release_Year | 2023 |
| Patent_ID | EP4253410 |