PPIPT01564

Target Protein Information
Protein_Name Endonuclease 8-like 3
Protein_Sequence MVEGPGCTLNGEKIRARVLPGQAVTGVRGSALRSLQGRALRLAASTVVVSPQAAALNNDSSQNVLSLFNGYVYSGVETLGKELFMYFGPKALRIHFGMKGFIMINPLEYKYKNGASPVLEVQLTKDLICFFDSSVELRNSMESQQRIRMMKELDVCSPEFSFLRAESEVKKQKGRMLGDVLMDQNVLPGVGNIIKNEALFDSGLHPAVKVCQLTDEQIHHLMKMIRDFSILFYRCRKAGLALSKHYKVYKRPNCGQCHCRITVCRFGDNNRMTYFCPHCQKENPQHVDICKLPTRNTIISWTSSRVDHVMDSVARKSEEHWTCVVCTLINKPSSKACDACLTSRPIDSVLKSEENSTVFSHLMKYPCNTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSPPASVCLNDIQHPSKKTTNDITQPSSKVNISPTISSESKLFSPAHKKPKTAQYSSPELKSCNPGYSNSELQINMTDGPRTLNPDSPRCSKHNRLCILRVVGKDGENKGRQFYACPLPREAQCGFFEWADLSFPFCNHGKRSTMKTVLKIGPNNGKNFFVCPLGKEKQCNFFQWAENGPGIKIIPGC
Organism_Source Homo sapiens
Functional_Classification DNA glycosylase / endonuclease
Cellular_Localization Nucleus
Gene_Names NEIL3
UniProt_ID Q8TAT5
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NEIL3-A24-9-591
Peptide_Sequence HWTCVWCTT
Peptide_Length 9
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1136.31
Aliphatic_Index 32.22222
Aromaticity 0.22222
Average_Rotatable_Bonds 3.22222
Charge_at_pH_7 -0.03506
Isoelectric_point 7.25316
Hydrogen_Bond_Acceptors 16
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 417.07000
X_logP_energy -2.65150
Interaction Information
Affinity KD=10 nM
Affinity_Assay NetMHC3.0 binding prediction
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title NEIL3 PEPTIDES AND VACCINES INCLUDING THE SAME
Release_Year 2012
Patent_ID US201200938.45A1