PPIPT01855

Target Protein Information
Protein_Name Immunoglobulin heavy constant alpha 1
Protein_Sequence ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGNREGPQY
Organism_Source Homo sapiens
Functional_Classification IgA heavy chain constant region
Cellular_Localization Extracellular
Gene_Names IGHA1
UniProt_ID P01876
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Opt2 15AA
Peptide_Sequence HMWCLSYRGRPWCFS
Peptide_Length 15
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C4<->C13; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1929.26
Aliphatic_Index 26.00000
Aromaticity 0.26667
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 1.96409
Isoelectric_point 8.80680
Hydrogen_Bond_Acceptors 25
Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 706.68000
X_logP_energy -3.90216
Interaction Information
Affinity KD=0.491 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title IGA-BINDING PEPTIDE AND IGA PURIFICATION USING THE SAME
Release_Year 2015
Patent_ID US20150044701A1