PPIPT01920

Target Protein Information
Protein_Name Germinal center-associated signaling and motility protein
Protein_Sequence MGNSLLRENRRQQNTQEMPWNVRMQSPKQRTSRCWDHHIAEGCFCLPWKKILIFEKRQDSQNENERMSSTPIQDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRESLGGTETEYSLLHMPSTDPRHARSPEDEYELLMPHRISSHFLQQPRPLMAPSETQFSHL
Organism_Source Homo sapiens
Functional_Classification Adaptor/scaffold protein
Cellular_Localization Extracellular
Gene_Names GCSAM
UniProt_ID Q8N6F7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Natural galanin
Peptide_Sequence GWTLNSAGYLLGPHAVGSHLMARLRALLA
Peptide_Length 29
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3046.59
Aliphatic_Index 121.37931
Aromaticity 0.06897
Average_Rotatable_Bonds 3.27586
Charge_at_pH_7 2.17895
Isoelectric_point 11.14775
Hydrogen_Bond_Acceptors 40
Hydrogen_Bond_Donors 43
Topological_Polar_Surface_Area 1190.29000
X_logP_energy -9.79296
Interaction Information
Affinity Ki=52.1 nM
Affinity_Assay Memo Radioimmunoassay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title STABILIZED BIOACTIVE PEPTIDES AND METHODS OF IDENTIFICATION, SYNTHESIS, AND USE
Release_Year 2006
Patent_ID US20060099571A1