PPIPT02105

Target Protein Information
Protein_Name Microtubule-associated protein tau
Protein_Sequence MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Organism_Source Homo sapiens
Functional_Classification Microtubule-stabilizing protein
Cellular_Localization Cytoplasm
Gene_Names MAPT
UniProt_ID P10636
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name na
Peptide_Sequence fwalfrfw
Peptide_Length 8
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1172.40
Aliphatic_Index 61.25000
Aromaticity 0.62500
Average_Rotatable_Bonds 3.87500
Charge_at_pH_7 0.99798
Isoelectric_point 10.55000
Hydrogen_Bond_Acceptors 10
Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 360.50000
X_logP_energy 3.29727
Interaction Information
Affinity IC50=0.54 uM
Affinity_Assay Thioflavin T assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title TAU AGGREGATION PEPTIDE INHIBITORS
Release_Year 2020
Patent_ID US20200216495A1