PPIPT02268

Target Protein Information
Protein_Name N-formyl peptide receptor 2
Protein_Sequence METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names FPR2
UniProt_ID P25090
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CCXP1
Peptide_Sequence AGMLWRRKIGPQMTLSHA
Peptide_Length 18
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@H](C)N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2053.47
Aliphatic_Index 76.11111
Aromaticity 0.05556
Average_Rotatable_Bonds 3.72222
Charge_at_pH_7 3.08859
Isoelectric_point 12.51648
Hydrogen_Bond_Acceptors 28
Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 827.07000
X_logP_energy -6.92286
Interaction Information
Affinity IC50=150 nM
Affinity_Assay intracellular calcium mobilization assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title COMPOSITIONS USEFUL AS LIGANDS FOR THE FORMYL PEPTIDE RECEPTOR LIKE 1 RECEPTOR AND METHODS OF USE THEREOF
Release_Year 2003
Patent_ID US20030096260A1