PPIPT02297
Target Protein Information
| Protein_Name | Transferrin receptor protein 1 |
|---|---|
| Protein_Sequence | MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF |
| Organism_Source | Homo sapiens |
| Functional_Classification | Iron uptake transmembrane receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | TFRC |
| UniProt_ID | P02786 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Y6-HDO |
|---|---|
| Peptide_Sequence | AVXVWNYYIIRRYXC |
| Peptide_Length | 15 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CS)C(=O)O)[C@@H](C)CC |
| Chemical_Modification | X3=N-methylphenylalanine; X12=D-arginine; X14=N-methyltyrosine |
| Cyclization_Method | Side chain-main chain cyclization; N1<-->C15; thioether bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1833.14 |
|---|---|
| Aliphatic_Index | 97.33333 |
| Aromaticity | 0.26667 |
| Average_Rotatable_Bonds | 3.60000 |
| Charge_at_pH_7 | 1.93345 |
| Isoelectric_point | 9.22221 |
|---|---|
| Hydrogen_Bond_Acceptors | 23 |
| Hydrogen_Bond_Donors | 28 |
| Topological_Polar_Surface_Area | 714.09000 |
| X_logP_energy | -3.22696 |
Interaction Information
| Affinity | KD=100 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Human transferrin receptor binding peptide-drug conjugate |
| Release_Year | 2024 |
| Patent_ID | EP4389893A1 |