PPIPT02351

Target Protein Information
Protein_Name Natural cytotoxicity triggering receptor 1
Protein_Sequence MSSTLPALLCVGLCLSQRISAQQQTLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVQFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTSLAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQNLLRMGLAFLVLVALVWFLVEDWLSRKRTRERASRASTWEGRRRLNTQTL
Organism_Source Homo sapiens
Functional_Classification NK cell activating receptor (Natural cytotoxicity receptor)
Cellular_Localization Plasma membrane
Gene_Names NCR1
UniProt_ID O76036
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pep4
Peptide_Sequence SGEKVTFYCRLDTATSMFLL
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2282.65
Aliphatic_Index 78.00000
Aromaticity 0.15000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 -0.06292
Isoelectric_point 6.31437
Hydrogen_Bond_Acceptors 33
Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 900.12000
X_logP_energy -7.96953
Interaction Information
Affinity KD=0.16 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 1OLL
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title PEPTIDES DERIVED FROM THE ECTODOMAIN OF NKP46
Release_Year 2017
Patent_ID EP3211002A2