PPIPT02353

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Sstr2
UniProt_ID P30680
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ga-IMP466
Peptide_Sequence DFCFWKTCT
Peptide_Length 9
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C3<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification free
C-terminal_Modification throl
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1150.33
Aliphatic_Index 0.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 -0.12581
Isoelectric_point 6.06420
Hydrogen_Bond_Acceptors 16
Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 415.69000
X_logP_energy -2.28900
Interaction Information
Affinity KD=13 nM
Affinity_Assay competitive binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules
Release_Year 2014
Patent_ID US20140017168A1