PPIPT02364

Target Protein Information
Protein_Name Gastrin-releasing peptide receptor
Protein_Sequence MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names GRPR
UniProt_ID P30550
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IMP468
Peptide_Sequence XGQWVWAVGHLM
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CN)C(C)C)C(C)C)C(=O)O
Chemical_Modification X1=NODA-NH-(CH2)2-CO
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification NODA
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1340.57
Aliphatic_Index 89.16667
Aromaticity 0.16667
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 0.08889
Isoelectric_point 7.55032
Hydrogen_Bond_Acceptors 16
Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 486.77000
X_logP_energy -1.56430
Interaction Information
Affinity IC50=21.5 nM
Affinity_Assay competitive binding assay on PC-3 cells
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules
Release_Year 2014
Patent_ID US20140377177A1