PPIPT02394

Target Protein Information
Protein_Name TGF-beta receptor type-1
Protein_Sequence MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Organism_Source Homo sapiens
Functional_Classification Serine/threonine kinase receptor
Cellular_Localization Plasma membrane
Gene_Names TGFBR1
UniProt_ID P36897
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Beta(41-65)-BSA
Peptide_Sequence ANFCLGPCPYIWSLDTQYSKVLALY-(BSA)
Peptide_Length 31
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2866.34
Aliphatic_Index 97.60000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.36000
Charge_at_pH_7 -0.12836
Isoelectric_point 6.05839
Hydrogen_Bond_Acceptors 38
Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 1030.81000
X_logP_energy -5.61520
Interaction Information
Affinity IC50=0.06 uM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title Peptide antagonists of TGF-beta family members and therapeutic uses thereof
Release_Year 2006
Patent_ID US20060233708A1