PPIPT02420

Target Protein Information
Protein_Name Alpha-synuclein
Protein_Sequence MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Organism_Source Homo sapiens
Functional_Classification Synaptic regulatory protein (alpha-synuclein family)
Cellular_Localization Cytoplasm
Gene_Names SNCA
UniProt_ID P37840
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KTKEGVLYVGSKTKE
Peptide_Sequence KTKEGVLYVGSKTKE
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1666.94
Aliphatic_Index 64.66667
Aromaticity 0.06667
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 1.99950
Isoelectric_point 10.02741
Hydrogen_Bond_Acceptors 26
Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 730.32000
X_logP_energy -7.24580
Interaction Information
Affinity KD=8.1 nM
Affinity_Assay competitive HLA binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Use of peptides as biomarkers in the diagnosis, confirmation and treatment of a neurological disorder and tcr and/or hla immunoprofiling in neurodegenerative disease
Release_Year 2020
Patent_ID US20200095296A1