PPIPT02478

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, A alpha chain
Protein_Sequence MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
Organism_Source Homo sapiens
Functional_Classification MHC class I antigen presentation receptor
Cellular_Localization Plasma membrane
Gene_Names HLA-A
UniProt_ID P01892
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IYTRVTYYL
Peptide_Sequence IYTRVTYYL
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1191.39
Aliphatic_Index 118.88889
Aromaticity 0.33333
Average_Rotatable_Bonds 3.77778
Charge_at_pH_7 0.99543
Isoelectric_point 9.06655
Hydrogen_Bond_Acceptors 16
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 459.17000
X_logP_energy -1.10533
Interaction Information
Affinity KD=342 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST PROSTATE CANCER AND OTHER CANCERS
Release_Year 2021
Patent_ID US20210283230A1