PPIPT02483
Target Protein Information
| Protein_Name | Ras-related protein Rab-3B |
|---|---|
| Protein_Sequence | MASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGQLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSLDTDPSMLGSSKNTRLSDTPPLLQQNCSC |
| Organism_Source | Homo sapiens |
| Functional_Classification | Small GTPase (Rab family) |
| Cellular_Localization | Cytoplasm |
| Gene_Names | RAB3B |
| UniProt_ID | P20337 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | RTFJPTYGL |
|---|---|
| Peptide_Sequence | RTFJPTYGL |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1011.15 |
|---|---|
| Aliphatic_Index | 43.33333 |
| Aromaticity | 0.22222 |
| Average_Rotatable_Bonds | 3.11111 |
| Charge_at_pH_7 | 0.99713 |
| Isoelectric_point | 9.34881 |
|---|---|
| Hydrogen_Bond_Acceptors | 14 |
| Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 409.92000 |
| X_logP_energy | -3.69233 |
Interaction Information
| Affinity | KD=328 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST PROSTATE CANCER AND OTHER CANCERS |
| Release_Year | 2021 |
| Patent_ID | US20210283230A1 |