PPIPT02484

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, A alpha chain
Protein_Sequence MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
Organism_Source Homo sapiens
Functional_Classification MHC class I antigen presentation receptor
Cellular_Localization Plasma membrane
Gene_Names HLA-A
UniProt_ID P04439
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name YLEPAIAKY
Peptide_Sequence YLEPAIAKY
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1067.25
Aliphatic_Index 108.88889
Aromaticity 0.22222
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 -0.00224
Isoelectric_point 6.39541
Hydrogen_Bond_Acceptors 14
Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 391.11000
X_logP_energy -0.19470
Interaction Information
Affinity KD=25 nM
Affinity_Assay radiolabeled peptide competition (gel filtration)
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions
Release_Year 2007
Patent_ID US20070020327A1