PPIPT02565

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, A alpha chain
Protein_Sequence MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
Organism_Source Homo sapiens
Functional_Classification MHC class I antigen presentation receptor
Cellular_Localization Plasma membrane
Gene_Names HLA-A
UniProt_ID P01892
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name INS-DRiP1-9 epitope
Peptide_Sequence MLYQHLLPL
Peptide_Length 9
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1127.41
Aliphatic_Index 173.33333
Aromaticity 0.11111
Average_Rotatable_Bonds 3.77778
Charge_at_pH_7 0.08804
Isoelectric_point 7.54235
Hydrogen_Bond_Acceptors 14
Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 379.33000
X_logP_energy 0.90000
Interaction Information
Affinity IC50=2.3 uM
Affinity_Assay competition-based cellular peptide binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title INSULIN GENE-DERIVED PROTEINS AND PEPTIDES FOR USE IN THE DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES
Release_Year 2019
Patent_ID US20190330297A1