PPIPT02572

Target Protein Information
Protein_Name POTE ankyrin domain family member D
Protein_Sequence MVAEVCSMPTASTVKKPFDLRSKMGKWCHHRFPCCRGSGKSNMGTSGDHDDSFMKMLRSKMGKCCRHCFPCCRGSGTSNVGTSGDHENSFMKMLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDHSAFMEPRYHIRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQEDECVLMLLEHGADRNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNVLDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRRSRKPENQQFPDTENEEYHSDEQNDTRKQLSEEQNTGISQDEILTNKQKQIEVAEQKMNSELSLSHKKEEDLLRENSVLQEEIAMLRLELDETKHQNQLRENKILEEIESVKEKTDKLLRAMQLNEEALTKTNI
Organism_Source Homo sapiens
Functional_Classification Ankyrin repeat-containing protein
Cellular_Localization Cytoplasm
Gene_Names POTED
UniProt_ID Q86YR6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name POTE222-230
Peptide_Sequence WLMLLEHGA
Peptide_Length 9
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1069.29
Aliphatic_Index 141.11111
Aromaticity 0.11111
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 -0.90933
Isoelectric_point 5.36351
Hydrogen_Bond_Acceptors 13
Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 377.89000
X_logP_energy 0.37400
Interaction Information
Affinity IC50=42.4 uM
Affinity_Assay T2 binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Immunogenic pote peptides and methods of use
Release_Year 2015
Patent_ID US20150010590A1