PPIPT02604
Target Protein Information
| Protein_Name | Fibroblast growth factor 5 |
|---|---|
| Protein_Sequence | MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG |
| Organism_Source | Homo sapiens |
| Functional_Classification | Fibroblast growth factor |
| Cellular_Localization | Extracellular |
| Gene_Names | FGF5 |
| UniProt_ID | P12034 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MM007-RTOPYPL-BLA |
|---|---|
| Peptide_Sequence | RTOPYPL |
| Peptide_Length | 7 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 802.93 |
|---|---|
| Aliphatic_Index | 55.71429 |
| Aromaticity | 0.14286 |
| Average_Rotatable_Bonds | 2.85714 |
| Charge_at_pH_7 | 0.99713 |
| Isoelectric_point | 9.34881 |
|---|---|
| Hydrogen_Bond_Acceptors | 11 |
| Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 322.70000 |
| X_logP_energy | -2.41063 |
Interaction Information
| Affinity | IC50=18 nM |
|---|---|
| Affinity_Assay | BioVeris receptor competition assay |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | FGF-5 SUPPORTED AND BINDING PEPTIDES |
| Release_Year | 2005 |
| Patent_ID | US20050238607A1 |