PPIPT02605
Target Protein Information
| Protein_Name | Fibroblast growth factor 5 |
|---|---|
| Protein_Sequence | MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG |
| Organism_Source | Homo sapiens |
| Functional_Classification | Fibroblast growth factor |
| Cellular_Localization | Extracellular |
| Gene_Names | FGF5 |
| UniProt_ID | P12034 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MM017-PLGLCPP-BLA |
|---|---|
| Peptide_Sequence | PLGLCPP |
| Peptide_Length | 7 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 695.87 |
|---|---|
| Aliphatic_Index | 111.42857 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.28571 |
| Charge_at_pH_7 | -0.06399 |
| Isoelectric_point | 5.92254 |
|---|---|
| Hydrogen_Bond_Acceptors | 9 |
| Hydrogen_Bond_Donors | 7 |
| Topological_Polar_Surface_Area | 206.35000 |
| X_logP_energy | -0.60240 |
Interaction Information
| Affinity | IC50=0.07 nM |
|---|---|
| Affinity_Assay | BioVeris receptor competition assay |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | FGF-5 SUPPORTED AND BINDING PEPTIDES |
| Release_Year | 2005 |
| Patent_ID | US20050238607A1 |