PPIPT02612
Target Protein Information
| Protein_Name | Protein E7 |
|---|---|
| Protein_Sequence | MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP |
| Organism_Source | Virus |
| Functional_Classification | Viral oncoprotein |
| Cellular_Localization | Cytoplasm |
| Gene_Names | E7 |
| UniProt_ID | P03129 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | A2.4 |
|---|---|
| Peptide_Sequence | TLGIVCPIC |
| Peptide_Length | 9 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)CC)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 918.18 |
|---|---|
| Aliphatic_Index | 162.22222 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.88889 |
| Charge_at_pH_7 | -0.12597 |
| Isoelectric_point | 5.82601 |
|---|---|
| Hydrogen_Bond_Acceptors | 13 |
| Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 307.56000 |
| X_logP_energy | -1.55100 |
Interaction Information
| Affinity | IC50=153 nM |
|---|---|
| Affinity_Assay | molecular binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Immunogenic peptides from the HPV E7 protein |
| Release_Year | 2001 |
| Patent_ID | US20010006639A1 |