PPIPT02613

Target Protein Information
Protein_Name RNA-binding protein 45
Protein_Sequence MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEELTRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFVGEQQSEFSSFDKNDSRGQEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGGSSGSQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVYLVSGKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY
Organism_Source Homo sapiens
Functional_Classification RNA-binding regulatory protein
Cellular_Localization Cytoplasm
Gene_Names RBM45
UniProt_ID Q8IUH3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pep100
Peptide_Sequence EAAKYEAYKAAAAAA
Peptide_Length 15
Peptide_SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1498.66
Aliphatic_Index 60.00000
Aromaticity 0.13333
Average_Rotatable_Bonds 3.13333
Charge_at_pH_7 -0.00076
Isoelectric_point 6.51743
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 637.82000
X_logP_energy -5.75120
Interaction Information
Affinity IC50=30 uM
Affinity_Assay ELISA
PDB_ID 1BX2
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Therapeutic peptides for demyelinating conditions
Release_Year 2003
Patent_ID US20030064915A1