PPIPT02693

Target Protein Information
Protein_Name Cytokine receptor-like factor 2
Protein_Sequence MGRLVLLWGAAVFLLGGWMALGQGGAAEGVQIQIIYFNLETVQVTWNASKYSRTNLTFHYRFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSIRNGTHPVFTASRWMVYYLKPSSPKHVRFSWHQDAVTVTCSDLSYGDLLYEVQYRSPFDTEWQSKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKFILISSLAILLMVSLLLLSLWKLWRVKKFLIPSVPDPKSIFPGLFEIHQGNFQEWITDTQNVAHLHKMAGAEQESGPEEPLVVQLAKTEAESPRMLDPQTEEKEASGGSLQLPHQPLQGGDVVTIGGFTFVMNDRSYVAL
Organism_Source Homo sapiens
Functional_Classification Class I cytokine receptor
Cellular_Localization Plasma membrane
Gene_Names CRLF2
UniProt_ID Q9HC73
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MTAAPVH
Peptide_Sequence MTAAPVH
Peptide_Length 7
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 725.86
Aliphatic_Index 70.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.71429
Charge_at_pH_7 0.08889
Isoelectric_point 7.55032
Hydrogen_Bond_Acceptors 11
Hydrogen_Bond_Donors 9
Topological_Polar_Surface_Area 278.04000
X_logP_energy -2.39120
Interaction Information
Affinity KD=3 nM
Affinity_Assay flow cytometry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all)
Release_Year 2015
Patent_ID US20150010475A1