PPIPT02697

Target Protein Information
Protein_Name Catenin beta-1
Protein_Sequence MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL
Organism_Source Homo sapiens
Functional_Classification Transcriptional co-activator (Wnt signaling pathway)
Cellular_Localization Cytoplasm
Gene_Names CTNNB1
UniProt_ID P35222
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SEQ ID NO:108
Peptide_Sequence LXTLRXIQRX
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O
Chemical_Modification X2=N-methylglycine; X6=beta-cyclobutylalanine; X10=2-naphthylalanine
Cyclization_Method Side chain-side chain cyclization; X6<-->X10; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1070.26
Aliphatic_Index 117.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 1.99798
Isoelectric_point 12.50011
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 512.34000
X_logP_energy -6.03316
Interaction Information
Affinity IC50=3160 nM
Affinity_Assay Wnt reporter gene assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title BCL9 Peptides and Variants Thereof
Release_Year 2020
Patent_ID US20200262867A1