PPIPT02700

Target Protein Information
Protein_Name Catenin beta-1
Protein_Sequence MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL
Organism_Source Homo sapiens
Functional_Classification Transcriptional co-activator (Wnt signaling pathway)
Cellular_Localization Cytoplasm
Gene_Names CTNNB1
UniProt_ID P35222
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SEQ ID NO:162
Peptide_Sequence HRQRSLQTLRXIQRX
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O
Chemical_Modification X11=Cpa; X15=2-naphthylalanine
Cyclization_Method Side chain-side chain cyclization; X11<-->X15; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1806.06
Aliphatic_Index 78.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.26667
Charge_at_pH_7 4.08888
Isoelectric_point 12.97715
Hydrogen_Bond_Acceptors 26
Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 916.73000
X_logP_energy -12.22492
Interaction Information
Affinity IC50=7050 nM
Affinity_Assay Wnt reporter gene assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title BCL9 Peptides and Variants Thereof
Release_Year 2020
Patent_ID US20200262867A1