PPIPT02736

Target Protein Information
Protein_Name Protein E7
Protein_Sequence MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP
Organism_Source Virus
Functional_Classification Viral oncoprotein
Cellular_Localization Cytoplasm
Gene_Names E7
UniProt_ID P03129
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name E2_271-300
Peptide_Sequence FNSSHKGRINCNSNTTPIWHLKGDANTLK
Peptide_Length 29
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3254.63
Aliphatic_Index 57.24138
Aromaticity 0.06897
Average_Rotatable_Bonds 3.68966
Charge_at_pH_7 3.11739
Isoelectric_point 10.50685
Hydrogen_Bond_Acceptors 49
Hydrogen_Bond_Donors 51
Topological_Polar_Surface_Area 1456.57000
X_logP_energy -19.60463
Interaction Information
Affinity IC50=0.15 uM
Affinity_Assay MHC class II binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Long peptides of 22-45 amino acid residues that induce and/or enhance antigen specific immune responses
Release_Year 2007
Patent_ID US20070292449A1