PPIPT02738

Target Protein Information
Protein_Name Protein E7
Protein_Sequence MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP
Organism_Source Virus
Functional_Classification Viral oncoprotein
Cellular_Localization Cytoplasm
Gene_Names E7
UniProt_ID P03129
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name E2_286-315
Peptide_Sequence TPIWHLKGDANTLKCLRYRFKKHCTLYTA
Peptide_Length 29
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3479.12
Aliphatic_Index 74.13793
Aromaticity 0.13793
Average_Rotatable_Bonds 3.86207
Charge_at_pH_7 5.05341
Isoelectric_point 10.24843
Hydrogen_Bond_Acceptors 48
Hydrogen_Bond_Donors 52
Topological_Polar_Surface_Area 1372.13000
X_logP_energy -10.04906
Interaction Information
Affinity IC50=68.0 uM
Affinity_Assay MHC class II binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Long peptides of 22-45 amino acid residues that induce and/or enhance antigen specific immune responses
Release_Year 2007
Patent_ID US20070292449A1