PPIPT02779

Target Protein Information
Protein_Name Adapter molecule crk
Protein_Sequence MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
Organism_Source Homo sapiens
Functional_Classification Adaptor protein (SH2/SH3 domain-containing)
Cellular_Localization Cytoplasm
Gene_Names CRK
UniProt_ID P46108
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name C3G
Peptide_Sequence PPPALPPKKR
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1100.37
Aliphatic_Index 49.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.90000
Charge_at_pH_7 2.99739
Isoelectric_point 11.82306
Hydrogen_Bond_Acceptors 14
Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 390.01000
X_logP_energy -2.20173
Interaction Information
Affinity KD=0.9 uM
Affinity_Assay fluorescence-based titration assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title SYNTHESIS OF PEPTIDE ALPHA-THOESTERS
Release_Year 2007
Patent_ID US20070129537A1