PPIPT02801

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Sstr2
UniProt_ID P30680
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name In-DTPA-octreotide
Peptide_Sequence fCFwKTCT
Peptide_Length 8
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)O
Chemical_Modification f1=D-phenylalanine; w4=D-tryptophan
Cyclization_Method Side chain-side chain cyclization; C2<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification DTPA
C-terminal_Modification Threoninol
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1035.24
Aliphatic_Index 0.00000
Aromaticity 0.37500
Average_Rotatable_Bonds 3.62500
Charge_at_pH_7 0.87374
Isoelectric_point 8.22969
Hydrogen_Bond_Acceptors 14
Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 349.29000
X_logP_energy -1.24850
Interaction Information
Affinity Ki=6.3 nM
Affinity_Assay competitive binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES
Release_Year 2012
Patent_ID US20120282178A1