PPIPT02805

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR2
UniProt_ID P30874
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IMP466 (Ga)
Peptide_Sequence DCFWKTCT
Peptide_Length 8
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C2<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification NOTA
C-terminal_Modification threoninol
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1003.16
Aliphatic_Index 0.00000
Aromaticity 0.25000
Average_Rotatable_Bonds 3.62500
Charge_at_pH_7 -0.12581
Isoelectric_point 6.06420
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 386.59000
X_logP_energy -3.01650
Interaction Information
Affinity IC50=13 nM
Affinity_Assay competitive binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES
Release_Year 2011
Patent_ID US20110110854A1