PPIPT02806

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR2
UniProt_ID P30874
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IMP466
Peptide_Sequence DFWKTCT
Peptide_Length 7
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)O
Chemical_Modification N-terminal NOTA; Cys2-Cys7 disulfide; C-terminal Thr-ol
Cyclization_Method Side chain-side chain cyclization; C2<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification NOTA
C-terminal_Modification Thr-ol
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 900.02
Aliphatic_Index 0.00000
Aromaticity 0.28571
Average_Rotatable_Bonds 3.71429
Charge_at_pH_7 -0.06384
Isoelectric_point 6.16057
Hydrogen_Bond_Acceptors 13
Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 357.49000
X_logP_energy -2.43110
Interaction Information
Affinity KD=3.6 nM
Affinity_Assay Competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES
Release_Year 2013
Patent_ID US20130315821A1