PPIST17797

Protein Information
Protein_Chain A;C
Protein_Sequence NVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNP
Peptide Information
Peptide_Chain B;D
Peptide_Sequence GFFLYPHGFYGIVC
Peptide_Length 14
Non-standard residues No
Interaction Information
PDB_ID 8YTE
Method X-RAY DIFFRACTION
Resolution 2.26 angstrom
Structure
Protein-peptide residue interaction
Residues
Acidic
Polar
Basic
Aliphatic
Aromatic
Interactions
HBond
WaterBridge
Hydrophobic
SaltBridge
PiStack
PiCation
Halogen
Metal
Interaction_xlsx Download interaction table (.xlsx)
Reference Information
Title Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists.
Release_Year 2024
PMID 38950284
DOI 10.1021/acs.jmedchem.4c00715