PPIDT00023
Drug Information
| Name | Antihemophilic factor, human recombinant |
|---|---|
| Sequence | ATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTIPENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPSPGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSSTSNNLISTIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEENNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTNKTSNNSATNRKTHIDGPSLLIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRLNHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSGQGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDNLHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYDGAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNTSQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKEKGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASYRKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLPKPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRPGKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSLNACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEEIDYDDTISVEMKKEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQDLY |
| DrugBank_ID | DB00025 |
| Type | biotech |
| Indication | The human recombinant antihemophilic factor is indicated for use in adults and children with hemophilia A for the control and prevention of bleeding episodes, perioperative management, and routine prophylaxis to prevent or reduce the frequency of bleeding episodes.[L41025, L36130] |
Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Injection, powder, for solution | Intravenous |
1500 IU
|
| Injection, powder, for solution | Intravenous; Parenteral |
100 UI
|
| Injection, powder, for solution | Intravenous; Parenteral |
1500 UI
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
125 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
250 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
400 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
500 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
600 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
750 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
800 [iU]/1mL
|
| Kit | Intravenous |
100 [iU]/1mL
|
| Kit | Intravenous |
125 [iU]/1mL
|
| Kit | Intravenous |
200 [iU]/1mL
|
| Kit | Intravenous |
250 [iU]/1mL
|
| Kit | Intravenous |
300 [iU]/1mL
|
| Kit | Intravenous |
400 [iU]/1mL
|
| Kit | Intravenous |
50 [iU]/1mL
|
| Kit | Intravenous |
500 [iU]/1mL
|
| Kit | Intravenous |
600 [iU]/1mL
|
| Kit | Intravenous |
750 [iU]/1mL
|
| Kit | Intravenous |
800 [iU]/1mL
|
| Powder, for solution | Intravenous |
1500 unit / vial
|
| Powder, for solution | Intravenous |
3000 unit / vial
|
| Solution | Intravenous |
500.000 UI
|
| Injection, powder, lyophilized, for solution | Intravenous |
1000 iu/5ml
|
| Injection, powder, lyophilized, for solution | Intravenous |
1500 IU
|
| Injection, powder, lyophilized, for solution | Intravenous |
1500 iu/5ml
|
| Injection, powder, lyophilized, for solution | Intravenous |
150000000 IU
|
| Injection, powder, lyophilized, for solution | Intravenous |
2000 iu/5ml
|
| Injection, powder, lyophilized, for solution | Intravenous |
200000000 IU
|
| Injection, powder, lyophilized, for solution | Intravenous |
250 iu/5ml
|
| Injection, powder, lyophilized, for solution | Intravenous |
|
| Injection, powder, lyophilized, for solution | Intravenous |
500 iu/5ml
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
1000 [iU]/2mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
1500 [iU]/2mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
250 [iU]/2mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
500 [iU]/2mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
750 [iU]/2mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
750 [iU]/5mL
|
| Injection, powder, for solution | Intravenous; Parenteral |
2500 UI
|
| Injection, powder, lyophilized, for solution | Parenteral |
|
| Powder | Parenteral |
1000 IU/10ml
|
| Powder | Parenteral |
2000 IU/10ml
|
| Powder | Parenteral |
250 IU/2.5ML
|
| Powder | Parenteral |
500 IU/5ML
|
| Injection, powder, lyophilized, for solution | Intravenous |
10000000 IU
|
| Injection, powder, for solution | Intravenous; Parenteral |
4000 UI
|
| Injection, powder, for solution | Intravenous; Parenteral |
5000 UI
|
| Injection, powder, for solution | Intravenous; Parenteral |
6000 UI
|
| Injection, powder, for solution | Intravenous; Parenteral |
750 UI
|
| Injection, powder, for solution | Intravenous |
1000 IU/30mL
|
| Injection, powder, lyophilized, for solution | Intravenous |
100 IU/10ml
|
| Injection, powder, lyophilized, for solution | Intravenous |
1000 IU/10ml
|
| Injection, powder, lyophilized, for solution | Intravenous |
250 IU/10ml
|
| Injection, powder, lyophilized, for solution | Intravenous |
3000 IU/10ml
|
| Injection, powder, lyophilized, for solution | Intravenous |
500 IU/10ml
|
| Injection, solution | Intravenous |
100 IU
|
| Injection, solution | Intravenous |
250 IU
|
| Injection, solution | Intravenous |
500 IU
|
| Powder, for solution | Parenteral |
1000 U.I.
|
| Powder, for solution | Parenteral |
250 U.I.
|
| Powder, for solution | Parenteral |
500 U.I.
|
| Injection, powder, for solution | Parenteral |
500000000 IU
|
| Injection, powder, for solution | Intravenous |
100 IU
|
| Injection, powder, for solution | Intravenous |
20 IU/mL
|
| Injection, powder, for solution | Intravenous |
250 IU
|
| Injection, solution | Intravenous |
100 IU/5ML
|
| Injection, solution | Intravenous |
1000 IU/10ML
|
| Injection, solution | Intravenous |
250 IU/10ML
|
| Injection, solution | Intravenous |
500 IU/20ML
|
| Injection, solution | Intravenous |
500 IU/10ML
|
| Powder, for solution | Parenteral |
250 UI
|
| Powder, for solution | Parenteral |
500 UI/10ML
|
| Powder, for solution | Intravenous; Parenteral |
1000 UI
|
| Powder, for solution | Intravenous; Parenteral |
250 UI
|
| Powder, for solution | Intravenous; Parenteral |
500 UI
|
| Injection, powder, lyophilized, for solution | Intravenous |
1000 IU
|
| Powder, for solution | Parenteral |
|
| Injection, powder, for solution | Intravenous |
3000 IU
|
| Injection, powder, for solution | Intravenous; Parenteral |
1000 UI
|
| Injection, powder, for solution | Intravenous; Parenteral |
250 UI
|
| Injection, powder, for solution | Intravenous; Parenteral |
500 UI
|
| Powder | Intravenous |
2000 UI
|
| Injection, powder, for solution | Intravenous |
3000 UI
|
| Injection, powder, for solution | — |
|
| Solution | Intravenous |
500 UI
|
| Injection, powder, for solution | Intravenous |
1000 IU
|
| Injection, powder, for solution | Intravenous |
1000 UI
|
| Injection, powder, for solution | Intravenous |
2000 UI
|
| Injection, powder, for solution | Intravenous |
2000 IU
|
| Injection, powder, for solution | Intravenous |
250 UI
|
| Injection, powder, for solution | Intravenous |
500 UI
|
| Injection, powder, for solution | Intravenous |
500 IU
|
| Powder | Intravenous |
3000 UI
|
| Injection, powder, lyophilized, for solution | Intravenous |
2000 iu
|
| Kit | Intravenous |
1000 [iU]/2.5mL
|
| Kit | Intravenous |
2000 [iU]/5mL
|
| Kit | Intravenous |
250 [iU]/2.5mL
|
| Kit | Intravenous |
3000 [iU]/5mL
|
| Kit | Intravenous |
500 [iU]/2.5mL
|
| Powder, for solution | Intravenous |
2000 unit / vial
|
| Injection, powder, lyophilized, for solution | Intravenous |
1000 IU/vial
|
| Injection, powder, lyophilized, for solution | Intravenous |
250 IU/vial
|
| Injection, powder, lyophilized, for solution | Intravenous |
500 IU/vial
|
| Injection, powder, lyophilized, for solution | Intravenous |
25000000 IU
|
| Injection, powder, for solution | Intravenous; Parenteral |
2000 UI
|
| Injection, powder, for solution | Intravenous; Parenteral |
3000 UI
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
1000 [iU]/2.5mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
250 [iU]/2.5mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
3000 [iU]/5mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
500 [iU]/2.5mL
|
| Kit; powder, for solution | Intravenous |
1000 unit / vial
|
| Kit; powder, for solution | Intravenous |
2000 unit / vial
|
| Kit; powder, for solution | Intravenous |
250 unit / vial
|
| Kit; powder, for solution | Intravenous |
3000 unit / vial
|
| Kit; powder, for solution | Intravenous |
500 unit / vial
|
| Solution | Intravenous |
2000 UI
|
| Injection, powder, for solution | Intravenous |
25000000 IU
|
| Injection, powder, lyophilized, for solution | Intravenous |
100000000 IU
|
| Injection, powder, lyophilized, for solution | Intravenous |
50000000 IU
|
| Injection, powder, lyophilized, for solution | Intravenous |
250 IU
|
| — | Intravenous |
|
| Powder | Intravenous |
1000 IU
|
| Powder | Intravenous |
1500 IU
|
| Powder | Intravenous |
250 IU
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
375 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
62.5 [iU]/1mL
|
| Injection, powder, for solution | Intravenous; Parenteral |
1000 IU
|
| Injection, powder, for solution | Intravenous; Parenteral |
2000 IU
|
| Injection, powder, for solution | Intravenous; Parenteral |
250 IU
|
| Injection, powder, for solution | Intravenous; Parenteral |
500 IU
|
| Injection, powder, for solution | Parenteral |
50 IU/ML
|
| Injection, powder, lyophilized, for solution | Intravenous |
|
| Injection, powder, for solution | Intravenous |
1000 IU/10ML
|
| Injection, powder, for solution | Intravenous |
250 IU/10ML
|
| Injection, powder, for solution | Intravenous |
500 IU/10ML
|
| Injection, powder, for solution | Parenteral |
1000 U.I./5ML
|
| Injection, powder, for solution | Parenteral |
1000 U.I./10ML
|
| Injection, powder, for solution | Parenteral |
250 U.I./5ML
|
| Injection, powder, for solution | Parenteral |
250 U.I./10ML
|
| Injection, powder, for solution | Parenteral |
500 U.I./5ML
|
| Injection, powder, for solution | Parenteral |
500 U.I./10ML
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
100 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
1000 [iU]/5mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
1500 [iU]/5mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
2000 [iU]/5mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
25 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
250 [iU]/5mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
50 [iU]/1mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
500 [iU]/5mL
|
| Solution | Intravenous |
|
| Powder, for solution | Intravenous |
1000 unit / vial
|
| Powder, for solution | Intravenous |
250 unit / vial
|
| Powder, for solution | Intravenous |
500 unit / vial
|
| Injection | Intravenous |
1000 IU/4ml
|
| Injection | Intravenous |
2000 IU/4ml
|
| Injection | Intravenous |
3000 IU/4ml
|
| Injection | Intravenous |
500 IU/4ml
|
| Solution | Intravenous |
250 IU/4ml
|
| Injection, powder, for solution | Parenteral |
|
| Injection, powder, for solution | Intravenous |
2500 UI
|
| Injection, powder, for solution | Intravenous |
4000 UI
|
| Powder | Intravenous |
500 IU
|
| Injection, powder, lyophilized, for solution | Intravenous |
500 IU
|
| Injection, solution | Intravenous |
|
| Injection, powder, for solution | Intravenous |
1000 iu/1vial
|
| Injection, powder, for solution | Intravenous |
250 iu/1vial
|
| Injection, powder, for solution | Intravenous |
500 iu/1vial
|
| Injection, powder, for solution | — |
1000 IU
|
| Injection, powder, for solution | — |
1500 IU
|
| Injection, powder, for solution | — |
250 IU
|
| Injection, powder, for solution | — |
500 IU
|
Target Information
| Role | Uniprot_ID | Gene_Name | Entity_Name | Organism | Actions | Internal link |
|---|---|---|---|---|---|---|
| target | P00742 | F10 | Coagulation factor X | Homo sapiens | activator | Link |
| target | P00740 | F9 | Coagulation factor IX | Homo sapiens | cofactor | Link |
| target | P04275 | VWF | von Willebrand factor | Homo sapiens | binder | Link |
| target | O14832 | PHYH | Phytanoyl-CoA dioxygenase, peroxisomal | Homo sapiens | antagonist | Link |
| target | P07307 | ASGR2 | Asialoglycoprotein receptor 2 | Homo sapiens | binder | Link |
| target | P11021 | HSPA5 | Endoplasmic reticulum chaperone BiP | Homo sapiens | chaperone | Link |
| target | P27797 | CALR | Calreticulin | Homo sapiens | chaperone | Link |
| target | P27824 | CANX | Calnexin | Homo sapiens | chaperone | Link |
| target | P49257 | LMAN1 | Protein ERGIC-53 | Homo sapiens | chaperone | Link |
| target | Q07954 | LRP1 | Prolow-density lipoprotein receptor-related protein 1 | Homo sapiens | modulator | Link |
| target | Q8NI22 | MCFD2 | Multiple coagulation factor deficiency protein 2 | Homo sapiens | modulator | Link |
| enzyme | P00734 | F2 | Prothrombin | Homo sapiens | activator | Link |
| enzyme | P04070 | PROC | Vitamin K-dependent protein C | Homo sapiens | substrate | Link |