PPIDT00046
Drug Information
| Name | Somatotropin |
|---|---|
| Sequence | FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF |
| DrugBank_ID | DB00052 |
| Type | biotech |
| Indication | Somatotropin is indicated for the treatment of pediatric patients who have growth failure due to an inadequate secretion of endogenous growth hormone, short stature associated with Turner syndrome, Prader-Willi syndrome (PWS), idiopathic short stature (ISS), short stature or growth failure in short stature homeobox-containing gene (SHOX) deficiency, and short stature born small for gestational age (SGA).[L31513, L31518] It is indicated for the treatment of growth failure in children associated with chronic kidney disease up to the time of renal transplantation.[L31523] It is also indicated for adults with adult-onset growth hormone deficiency, either alone or associated with multiple hormone deficiencies (hypopituitarism), as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or trauma. It is also used to treat childhood-onset growth hormone deficiency in adults due to congenital, genetic, acquired, or idiopathic causes.[L31518] Somatotropin is indicated for the treatment of wasting or cachexia in patients with human immunodeficiency virus (HIV) who are receiving antiretroviral therapy to increase lean body mass and body weight and improve physical endurance.[L31498] Somatotropin is indicated for the treatment of short bowel syndrome in adult patients receiving specialized nutritional support.[L31493] |
Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Powder | — |
|
| Liquid; powder, for solution | Subcutaneous |
|
| Injection, powder, for solution | Parenteral |
0.2 MG
|
| Injection, powder, for solution | Parenteral |
0.4 MG
|
| Injection, powder, for solution | Parenteral |
0.6 MG
|
| Injection, powder, for solution | Parenteral |
0.8 MG
|
| Injection, powder, for solution | Parenteral |
1 MG
|
| Injection, powder, for solution | Parenteral |
1.2 MG
|
| Injection, powder, for solution | Parenteral |
1.4 MG
|
| Injection, powder, for solution | Parenteral |
1.6 MG
|
| Injection, powder, for solution | Parenteral |
1.8 MG
|
| Injection, powder, for solution | Parenteral |
2 MG
|
| Injection, powder, for solution | Subcutaneous |
12 mg
|
| Injection, powder, for solution | Subcutaneous |
3 IU
|
| Injection, powder, for solution | Subcutaneous |
4 IU
|
| Injection, powder, for solution | Subcutaneous |
5 mg
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
0.2 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
0.4 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
0.6 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
0.8 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
1 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
1.2 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
1.4 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
1.6 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
1.8 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
12 mg/1mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
2 mg/0.25mL
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
5 mg/1mL
|
| Kit | Subcutaneous |
0.2 mg/0.25mL
|
| Kit | Subcutaneous |
0.4 mg/0.25mL
|
| Kit | Subcutaneous |
0.6 mg/0.25mL
|
| Kit | Subcutaneous |
0.8 mg/0.25mL
|
| Powder, for solution | Subcutaneous |
0.2 mg / syr
|
| Powder, for solution | Subcutaneous |
0.4 mg / syr
|
| Powder, for solution | Subcutaneous |
0.6 mg / syr
|
| Powder, for solution | Subcutaneous |
0.8 mg / syr
|
| Powder, for solution | Subcutaneous |
1 mg / syr
|
| Powder, for solution | Subcutaneous |
1.2 mg / syr
|
| Powder, for solution | Subcutaneous |
1.4 mg / syr
|
| Powder, for solution | Subcutaneous |
1.6 mg / syr
|
| Powder, for solution | Subcutaneous |
1.8 mg / syr
|
| Powder, for solution | Subcutaneous |
12 mg / pen
|
| Powder, for solution | Subcutaneous |
2 mg / syr
|
| Powder, for solution | Subcutaneous |
5 mg / pen
|
| Powder, for solution | Subcutaneous |
5.3 mg / pen
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
12 mg
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
1200000 mg
|
| Injection, powder, for solution | Parenteral |
|
| Injection | Subcutaneous |
16 iu
|
| Injection | Subcutaneous |
36 iu
|
| Injection, powder, for solution | Parenteral |
5.3 mg
|
| Solution | Parenteral |
13.8 mg
|
| Injection, powder, for solution | Intramuscular; Subcutaneous |
5.3 mg/ml
|
| Injection, powder, for solution | — |
5.3 mg
|
| Injection, powder, for solution | Subcutaneous |
5.3 mg
|
| Solution | Intramuscular; Subcutaneous |
800000 IU
|
| Solution | Intramuscular; Subcutaneous |
1600000 IU
|
| Injection, powder, for solution | Parenteral |
24 MG
|
| Injection, powder, for solution | Parenteral |
6 MG
|
| Injection, powder, lyophilized, for solution | Intramuscular; Subcutaneous |
5.33 mg
|
| Kit | Intramuscular; Subcutaneous |
12 mg/2.88mL
|
| Kit | Intramuscular; Subcutaneous |
24 mg/2.88mL
|
| Kit | Intramuscular; Subcutaneous |
5 mg/5mL
|
| Kit | Intramuscular; Subcutaneous |
6 mg/2.88mL
|
| Liquid; powder, for solution | Intramuscular; Subcutaneous |
|
| Injection, powder, for solution | Parenteral |
12 mg
|
| Injection | Subcutaneous |
18 iu
|
| Injection | Subcutaneous |
72 iu
|
| Solution | — |
1.33 mg
|
| Solution | Parenteral |
4 UI
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
1.33 mg
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
4 mg
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
8 mg
|
| Injection, solution | Subcutaneous |
10 mg/1.5mL
|
| Injection, solution | Subcutaneous |
15 mg/1.5mL
|
| Injection, solution | Subcutaneous |
30 mg/3mL
|
| Injection, solution | Subcutaneous |
5 mg/1.5mL
|
| Injection | Subcutaneous |
400000 IU
|
| Injection, solution | Parenteral |
|
| Injection, solution | Parenteral |
10 mg/1.5ml
|
| Injection, solution | Parenteral |
15 mg/1.5ml
|
| Injection, solution | Parenteral |
5 mg/1.5ml
|
| Solution | Subcutaneous |
10 mg / 1.5 mL
|
| Solution | Subcutaneous |
6.7 mg
|
| Solution | Subcutaneous |
10 mg
|
| Solution | Subcutaneous |
1000000 mg
|
| Solution | Subcutaneous |
330000 mg
|
| Injection | Subcutaneous |
10 mg/1.5ml
|
| Injection | Subcutaneous |
5 mg/1.5ml
|
| Solution | Subcutaneous |
15 mg / 1.5 mL
|
| Solution | Subcutaneous |
5 mg / 1.5 mL
|
| Kit | Subcutaneous |
10 mg/10mg
|
| Kit | Subcutaneous |
5 mg/5mg
|
| Kit; powder, for solution | Intramuscular; Subcutaneous |
|
| Injection, solution | Subcutaneous |
10 mg/2mL
|
| Liquid | Subcutaneous |
5 mg / mL
|
| Solution | Subcutaneous |
10 mg / 2 mL
|
| Solution | Subcutaneous |
20 mg / 2 mL
|
| Injection, solution | Subcutaneous |
5 mg/2mL
|
| Solution | Subcutaneous |
5 mg / 2 mL
|
| Injection, solution | Subcutaneous |
20 mg/2mL
|
| Kit | Subcutaneous |
13.5 mg/1mL
|
| Kit | Subcutaneous |
18 mg/1mL
|
| Kit | Subcutaneous |
22.5 mg/1mL
|
| Injection, solution | Subcutaneous |
10 mg
|
| Injection | Subcutaneous |
15 mg/1.5ml
|
| Injection, powder, for solution | Subcutaneous |
1.3 MG/ML
|
| Injection, powder, for solution | Subcutaneous |
5 MG/ML
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
5.8 mg/1mL
|
| Injection, solution | Parenteral; Subcutaneous |
10 MG/1.5ML
|
| Injection, solution | Parenteral; Subcutaneous |
15 MG/1.5ML
|
| Injection, solution | Parenteral; Subcutaneous |
5 MG/1.5ML
|
| Kit | Subcutaneous |
1.5 mg/1.13mL
|
| Kit; powder, for solution | Subcutaneous |
|
| Solution | Subcutaneous |
5 mg
|
| Injection, solution | Subcutaneous |
15 mg
|
| Injection, solution | Subcutaneous |
5 mg
|
| Solution | Subcutaneous |
670000 mg
|
| Solution | Parenteral |
1.33 mg
|
| Injection | Subcutaneous |
5.83 mg/ml
|
| Injection, powder, for solution | Intramuscular; Subcutaneous |
0.67 MG
|
| Injection, powder, for solution | Subcutaneous |
8 mg
|
| Injection, powder, lyophilized, for solution | Intramuscular; Subcutaneous |
1.33 MG
|
| Injection, powder, lyophilized, for solution | Intramuscular; Subcutaneous |
3.33 MG
|
| Injection, powder, lyophilized, for solution | Intramuscular; Subcutaneous |
8 MG
|
| Injection, solution | — |
5.83 MG/ML
|
| Kit | Intramuscular; Subcutaneous |
5 mg/3mL
|
| Kit | Intramuscular; Subcutaneous |
8.8 mg/3mL
|
| Powder, for solution | Intramuscular; Subcutaneous |
5 mg / vial
|
| Solution | Subcutaneous |
1.330 mg
|
| Solution | Subcutaneous |
5.83 mg / mL
|
| Solution | Subcutaneous |
8 mg / mL
|
| Solution | Subcutaneous |
800000 mg
|
| Solution | Subcutaneous |
20 mg
|
| Powder, for solution | Intramuscular; Subcutaneous |
|
| Injection, solution | Subcutaneous |
12 mg/1.5ml
|
| Injection, solution | Subcutaneous |
20 mg/2.5ml
|
| Injection, powder, for solution | Subcutaneous |
3.33 mg
|
| Injection | Subcutaneous |
|
| Injection, solution | — |
|
| Injection, solution | Subcutaneous |
6 mg/1.03ml
|
| Injection, solution | — |
8 mg/ml
|
| Powder, for solution | Subcutaneous |
8.8 mg / vial
|
| Injection, solution | Subcutaneous |
8 mg
|
| Kit | Intramuscular; Subcutaneous |
8.8 mg/1.51mL
|
| — | — |
8 mg
|
| — | — |
|
| Injection, powder, for solution | Intramuscular; Subcutaneous |
3.33 mg
|
| Injection, solution | — |
8 mg/1ml
|
| Injection, solution | — |
5.83 mg/1ml
|
| Injection, solution | Subcutaneous |
|
| Injection, solution | Subcutaneous |
6.0 mg/ml
|
| Injection, solution | Subcutaneous |
12 mg/ml
|
| Injection, solution | Subcutaneous |
20 mg/ml
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
133000 mg
|
| Solution | Subcutaneous |
6 mg
|
| Solution | Subcutaneous |
600000 mg
|
| Kit | Subcutaneous |
4 mg/1mL
|
| Kit | Subcutaneous |
5 mg/1mL
|
| Kit | Subcutaneous |
6 mg/1mL
|
| Kit | Subcutaneous |
8.8 mg/2mL
|
| Powder, for solution | Subcutaneous |
|
| Injection, powder, lyophilized, for solution | Intramuscular; Subcutaneous |
133000 mg
|
| Injection, powder, for suspension, extended release | Subcutaneous |
10 MG
|
| Injection, powder, for suspension, extended release | Subcutaneous |
2 MG
|
| Injection, powder, for suspension, extended release | Subcutaneous |
20 MG
|
| Injection, powder, for suspension, extended release | Subcutaneous |
4 MG
|
| Injection, powder, for suspension, extended release | Subcutaneous |
7 MG
|
| Kit | Subcutaneous |
10 mg/1
|
| Kit | Subcutaneous |
10 mg/10mL
|
| Kit | Subcutaneous |
5 mg/1
|
| Injection, powder, for solution | Subcutaneous |
15 mg/1.5ml
|
| Solution | Subcutaneous |
18.000 UI
|
| Solution | Parenteral |
4.00 UI
|
| Injection, powder, for solution | — |
10 MG/ML
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
1.3 mg
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
4 IU
|
| Injection, powder, lyophilized, for solution; kit | Subcutaneous |
5 mg/1
|
| Injection, powder, for solution | — |
4 mg/1vial
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
|
| Injection, powder, for solution | Subcutaneous |
10.0 mg
|
| Injection, powder, for solution | Subcutaneous |
4 mg
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
400000 mg
|
| Kit | Subcutaneous |
8.8 mg/1mL
|
| Solution | — |
10 mg/1.5ml
|
| Solution | — |
5 mg/1.5ml
|
| Powder | — |
1.6 mg/1vial
|
| Injection, powder, for solution | — |
10 mg/1ml
|
Target Information
| Role | Uniprot_ID | Gene_Name | Entity_Name | Organism | Actions | Internal link |
|---|---|---|---|---|---|---|
| target | P10912 | GHR | Growth hormone receptor | Homo sapiens | ligand | Link |
| target | P16471 | PRLR | Prolactin receptor | Homo sapiens | ligand | Link |
| enzyme | P05177 | CYP1A2 | Cytochrome P450 1A2 | Homo sapiens | inducer | Link |
| enzyme | P33261 | CYP2C19 | Cytochrome P450 2C19 | Homo sapiens | inhibitor | Link |
| transporter | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | Homo sapiens | substrate | Link |