PPIDT00087

Drug Information
NameNatalizumab
SequenceQVQLVQSGAEVKKPGASVKVSCKASGFNIKDTYIHWVRQAPGQRLEWMGRIDPANGYTKYDPKFQGRVTITADTSASTAYMELSSLRSEDTAVYYCAREGYYGNYGVYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
DrugBank_IDDB00108
Typebiotech
IndicationNatalizumab is indicated as monotherapy for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.[L48031, L48036, L49096] It is also indicated for inducing and maintaining clinical response and remission in adult patients with moderately to severely active Crohn’s disease with evidence of inflammation who have had an inadequate response to or are unable to tolerate, conventional therapies and inhibitors of TNF-α. It is not to be used in combination with immunosuppressants or inhibitors of TNF-α.[L48031, L48036]
Dosage Forms
Form Route Strength
— Intravenous
300 mg
Injection, solution, concentrate Intravenous
300 mg
Injection Intravenous
300 mg/15mL
Injection, solution Subcutaneous
150 MG
Injection, solution, concentrate Intravenous
150 mg
Injection, solution, concentrate Intravenous; Parenteral
300 MG
Solution Intravenous
300 mg / 15 mL
Solution Intravenous
300 mg
Solution Intravenous
300 mg/15mL
Solution Subcutaneous
150.00 mg
Solution, concentrate Intravenous
300 mg
Solution, concentrate Intravenous
30000000 mg
Injection, solution, concentrate Intravenous
20 mg/1ml
Target Information
Role Uniprot_ID Gene_Name Entity_Name Organism Actions Internal link
target P13612 ITGA4 Integrin alpha-4 Homo sapiens antibody Link
target O75015 FCGR3B Low affinity immunoglobulin gamma Fc region receptor III-B Homo sapiens ligand Link
target P12314 FCGR1A High affinity immunoglobulin gamma Fc receptor I Homo sapiens ligand Link
target P05362 ICAM1 Intercellular adhesion molecule 1 Homo sapiens ligand Link