PPIDT00106

Drug Information
NameMecasermin
SequenceGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
DrugBank_IDDB01277
Typebiotech
IndicationFor the long-term treatment of growth failure in pediatric patients with Primary IGFD or with GH gene deletion who have developed neutralizing antibodies to GH [A2322]. It is not indicated to treat Secondary IGFD resulting from GH deficiency, malnutrition, hypothyroidism or other causes; it is not a substitute for GH therapy.
Dosage Forms
Form Route Strength
Patch Topical
Injection, solution Parenteral; Subcutaneous
10 MG/ML
Injection, solution Subcutaneous
10 mg/ml
Injection, solution Subcutaneous
40 mg/4mL
Solution Subcutaneous
40 mg / 4 mL
Target Information
Role Uniprot_ID Gene_Name Entity_Name Organism Actions Internal link
target P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens agonist Link
target P17936 IGFBP3 Insulin-like growth factor-binding protein 3 Homo sapiens unknown Link
target P06213 INSR Insulin receptor Homo sapiens unknown Link
target P11717 IGF2R Cation-independent mannose-6-phosphate receptor Homo sapiens unknown Link
carrier P17936 IGFBP3 Insulin-like growth factor-binding protein 3 Homo sapiens carrier Link
carrier P35858 IGFALS Insulin-like growth factor-binding protein complex acid labile subunit Homo sapiens carrier Link
carrier P08833 IGFBP1 Insulin-like growth factor-binding protein 1 Homo sapiens carrier Link
carrier P18065 IGFBP2 Insulin-like growth factor-binding protein 2 Homo sapiens carrier Link
carrier P22692 IGFBP4 Insulin-like growth factor-binding protein 4 Homo sapiens carrier Link
carrier P24593 IGFBP5 Insulin-like growth factor-binding protein 5 Homo sapiens carrier Link
carrier P24592 IGFBP6 Insulin-like growth factor-binding protein 6 Homo sapiens carrier Link