PPIDT00208
Drug Information
| Name | Human C1-esterase inhibitor |
|---|---|
| Sequence | Not Available |
| DrugBank_ID | DB06404 |
| Type | biotech |
| Indication | Intravenous and subcutaneous formulations of the human C1-esterase inhibitor are indicated for routine prophylaxis against acute attacks of hereditary angioedema in patients six years of age and older.[L16586, L16606] It is also used to treat these in adult and adolescent patients with hereditary angioedema.[L40995] |
Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Injection, powder, for solution | Intravenous |
1500 IU
|
| Injection, powder, for solution | Intravenous |
2000 IU
|
| Injection, powder, for solution | Intravenous |
3000 IU
|
| Injection, powder, for solution | Intravenous |
500 IU
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
500 [iU]/10mL
|
| Kit; powder, for solution | Intravenous |
1500 unit / vial
|
| Kit; powder, for solution | Intravenous |
500 unit / vial
|
| Injection, powder, for solution | Intravenous |
500 U
|
| Injection, powder, lyophilized, for solution | Intravenous |
500 [iU]/5mL
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
500 [iU]/5mL
|
| Powder, for solution | Intravenous |
500 unit / vial
|
| Injection, solution | Intravenous |
500 iu/5ml
|
| Kit; powder, for solution | Subcutaneous |
2000 unit / vial
|
| Kit; powder, for solution | Subcutaneous |
3000 unit / vial
|
| Injection, powder, for solution; kit | Subcutaneous |
2000 [iU]/4mL
|
| Injection, powder, for solution; kit | Subcutaneous |
3000 [iU]/6mL
|
Target Information
| Role | Uniprot_ID | Gene_Name | Entity_Name | Organism | Actions | Internal link |
|---|---|---|---|---|---|---|
| target | P00736 | C1R | Complement C1r subcomponent | Homo sapiens | inhibitor | Link |
| target | P09871 | C1S | Complement C1s subcomponent | Homo sapiens | inhibitor | Link |
| target | P03952 | KLKB1 | Plasma kallikrein | Homo sapiens | inhibitor | Link |
| target | P00748 | F12 | Coagulation factor XII | Homo sapiens | inhibitor | Link |
| target | P03951 | F11 | Coagulation factor XI | Homo sapiens | inhibitor | Link |
| target | P00750 | PLAT | Tissue-type plasminogen activator | Homo sapiens | inhibitor | Link |
| target | P00734 | F2 | Prothrombin | Homo sapiens | inhibitor | Link |