PPIDT00254

Drug Information
NameSiltuximab
SequenceEVQLVESGGKLLKPGGSLKLSCAASGFTFSSFAMSWFRQSPEKRLEWVAEISSGGSYTYYPDTVTGRFTISRDNAKNTLYLEMSSLRSEDTAMYYCARGLWGYYALDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
DrugBank_IDDB09036
Typebiotech
IndicationSiltuximab is indicated for the treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative. Siltuximab did not bind to virally produced IL-6 in a nonclinical study and was therefore not studied in patients with MCD who are HIV or HHV-8 positive.

Dosage Forms
Form Route Strength
Injection, powder, for solution Intravenous
100 mg/1
Injection, powder, for solution Intravenous
400 mg/1
Injection, powder, for solution Intravenous; Parenteral
100 MG
Injection, powder, for solution Intravenous; Parenteral
400 MG
Injection, powder, lyophilized, for solution Intravenous
100 mg/1
Injection, powder, lyophilized, for solution Intravenous
400 mg/1
Powder, for solution Intravenous
100 mg / vial
Powder, for solution Intravenous
400 mg / vial
Injection Parenteral
Injection Parenteral
100 mg
Injection, powder, for solution Intravenous
100 mg
Injection Parenteral
400 mg
Injection, powder, for solution Intravenous
400 mg
Injection, powder, lyophilized, for solution Intravenous
100 mg
Injection, powder, lyophilized, for solution Intravenous
400 mg
Injection, solution, concentrate Intravenous
100 mg/1vial
Target Information
Role Uniprot_ID Gene_Name Entity_Name Organism Actions Internal link
target P05231 IL6 Interleukin-6 Homo sapiens antagonist|antibody Link
enzyme P08684 CYP3A4 Cytochrome P450 3A4 Homo sapiens inducer Link